Criteria diagnosis IPF without open lung biopsy

Criteria diagnosis IPF without open lung biopsy

Major Criteria (all 4 needed)
1.Exclusion of other known causes of ILD such as certain drug toxicities, environmental exposures, and connective tissue diseases
2.Abnormal pulmonary function studies that include evidence of restriction (reduced VC, often with an increased FEV1/FVC ratio) and impaired gas exchange [increased P(A–a)O2, decreased PaO2 with rest or exercise or decreased DLCO]
3.Bibasilar reticular abnormalities with minimal ground glass opacities on HRCT scans
4.Transbronchial lung biopsy or BAL showing no features to support an alternative diagnosis

Minor Criteria (3/4 needed)
1.Age >50 yr
2.Insidious onset of otherwise unexplained dyspnea on exertion
3.Duration of illness >3 mo
4.Bibasilar, inspiratory crackles (dry or “Velcro”-type in quality)

From ATS/ERS