Risk for TB

-Patients with certain clinical conditions that place them at risk (e.g., silicosis, diabetes mellitus, chronic renal failure, leukemia, lymphoma, other malignancies [e.g., carcinomas of the head and lung], weight loss of >10% of ideal body weight, gastrectomy, and jejunoileal bypass
-จริงๆ มัน เกี่ยวกับ BW และเรื่อง malnutrition ด้วย
-silica enter macrophage and damage มัน prone infection
เช่นเดียวกับcoal worker pneumoconiosis
-แถมมันยังปล่อย antigen cytokine cause pulmonary fibrosis ด้วย
-อีก theory ก็เกี่ยวกับ iron ด้วย
-anti-tuberculous glycolipid (TBGL) antibody ต่ำลงใน pt gastrectomy
-‎5-12 in gastrectomy and 27-63 in jejunoileal bypass. In patients with chronic renal failur the relative risk ranges from 10 (nephropathies) to 37 (transplantation). Numerous patients use long-term immunosuppressive therapy that contributes to increased risk for developing tuberculosis (relative risk 12) as early as one month after application of a dose above 15 mg/day
-Chronic renal failure ass with uremic toxin and vitamin D metabolism